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KMID : 0816120070100020173
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2007 Volume.10 No. 2 p.173 ~ p.178
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Clinical Features and Natural Course of Benign Transient Hyperphosphatasemia in Children
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Oh Dae-Sung
Choi Jung-Yun
Seo Jeong-Kee
Ko Jae-Sung
Yang Hye-Ran
Jang Ju-Young
Han Jae-Joon
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Abstract
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Purpose: This study was conducted to analyze the clinical manifestation and natural course of benign transient hyperphosphatasemia (BTH) in children.
Methods: A total of 17 children diagnosed with BTH between June 2006 and July 2007, were included in this study. Clinical records and laboratory tests were analyzed retrospectively for all children.
Results: The mean age of the patients was 26.9±13.8 months (range: 9 to 49 months). Nine of the 17 BTH cases (52.9%) occurred in patients that had previously suffered from infectious diseases. While the patients were suffering from BTH, the mean serum level of alkaline phosphatase (ALP) was 2,500.2± 1,165.1 U/L, however, these elevated serum ALP levels normalized within 7 weeks of recovery in all cases. In addition, a seasonal peak in the onset of BTH was observed from September to December. Further, the measurement of ALP isoenzymes in 7 of the patients with BTH, revealed a marked elevation of bone fraction.
Conclusion: It is important for pediatricians to understand the clinical manifestation and benign course of BTH to avoid unnecessary diagnostic evaluation in children showing a transient increase in ALP activities. (Korean J Pediatr Gastroenterol Nutr 2007; 10: 173∼178)
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KEYWORD
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Benign transient hyperphosphatasemia, Alkaline phosphatase (ALP), Children
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